Principal Assoc Pharmaceutical Development Scientist

Jazz Pharmaceuticals

Sittingbourne, United Kingdom

Brief Description

Implement and develop new processes and optimise drug substance scale up activities. Play a vital role in contributing and delivering pharmaceutical APIs. Use of chemical knowledge to prepare a wide range of compounds intermediates and API during drug development phases. Execute the synthesis, analysis, separation and/or purification on small (mg) to intermediate scales, supporting drug substance process development activities.

Essential Functions/Responsibilities

Maintain and provide in-depth knowledge and expertise on the drug development process;
Demonstrate competency and innovation on a range of complex laboratory skills and equipment;
Practical and theoretical understanding in a range of skills and technologies;
Maintain industry knowledge and keep abreast of relevant new technologies;
Record and review all experimental outcomes in an appropriate format;
Report and communicate project outcomes in an appropriate manner;
Interact with technical colleagues internally and external support businesses/CDMOs;
Identify and resolve promptly any problems occurring at any phase of a study, escalating to the line manager where necessary;
Maintain all areas of the laboratory in clean and tidy state;
Coach and mentor less experienced colleagues as required;
Ensure training record is maintained to cGxP;
Ensure all applicable quality measures are met and adhered to;
Assist in the creation and maintenance of all relevant cGxP documents;
The role holder is responsible for maintaining cGxP and health and safety knowledge relevant to the role;
Contribute to regulatory documentation;
Contribute to process driven continuous improvement initiatives.

Required Knowledge, Skills, and Abilities

Proven communication skills including written and presentational;
Excellent attention to detail;
Coaching and mentoring of less experienced colleagues;
Awareness of basic statistical principles;
Evaluate process improvements in collaboration with colleagues;
Use of a range of laboratory equipment (Purification and isolation techniques, NMR and LC-MS for structural determination);
Excellent working knowledge of HPLC;
Exhibit highly effective teamworking and communication skills as well as a motivation to solve synthetic and process chemistry problems;
Work in close partnership with analytical and engineering colleagues;
Maintain the highest standards of GMP, health and safety.