Senior Research Scientist - Neurodegeneration

Senior Research Scientist - Neurodegeneration

Evotec

Hamburg, Germany

At Evotec’s headquarters in Hamburg, Germany, the Protein Interactions Team is seeking a highly motivated and dedicated Senior Research Scientist (all genders) - Neurodegeneration, Full-time and permanent.

Your key responsibilities:

• Establish and implement readouts for lysosomal (dys)function using biochemical and cellular assays as well as Omics techniques
• Develop and supervise cellular assay systems based on iPSC neurons and neuronal cell lines
• Develop assays to address the effect of pharmacological as well as genetic perturbations on lysosomal pathways
• Leading cross-functional project teams to support preclinical drug discovery in the early drug discovery stages
• Plan, organize and supervise the work of technical staff
• Train and support staff in development of management and technical skills

Your ideal qualifications:

• PhD in biology, biochemistry or an equivalent Life Science and a minimum of five years professional experience (Pharma or Biotech)
• Strong background in lysosomal biology
• Profound experience with various techniques to manipulate and measure lysosomal function
• Experience with Immunoassays (such as HTRF, MSD, ELISA), Immunocytochemistry (ICC), fractionation assays and Omics techniques (Proteomics, Transcriptomics, Lipidomics, Metabolomics)
• Experience with analysis of large datasets would be a plus
• High level of understanding of protein biochemistry, protein folding and neurodegenerative disorders
• Substantial experience with assays based on neuronal cell cultures, ideally iPSC-derived cells
• Proven excellence in biochemical and cellular assay development and a mindset to tweak and optimize assay parameters until highly reproducible and quality-controlled assay results are achieved
• Track record of collaborating with other scientists
• High degree of initiative and flexibility, with the ability to deliver results under challenging timelines
• Good organizational skills and the ability to lead a team of scientists and research assistants
• Good English verbal and written communication skills, German advantageous
• Strong publication record and demonstrated experience with conducting independent research

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