Scientist in Chemistry

Coave Therapeutics

Strasbourg, France

We are looking for a motivated candidate with solid experience in Organic and Bioconjugation Chemistry.

The successful candidate will be a major scientific contributor to the project providing expertise on chemical synthesis and bioconjugation chemistry. Under the responsibility of the Head of Medicinal Chemistry based in Paris, and in close collaboration with the Director of the Academic Lab in Strasbourg, the Scientist will be responsible for developing innovative chemical ligands for the bioconjugation to AAV to reinforce the current R&D programs. S/he will work in transversal interaction with scientists from the Aligater platform located at ICM (Paris 13).

Responsibilities

Conception and design of new chemical ligands according to pre-defined strategy for AAV bioconjugation;
Completion of multi-step, high quality, reproducible organic chemistry synthesis of compounds according to agreed objectives and deadlines;
Optimize ligand design according to bioconjugation efficiency, AAV serotypes and to adapt to multiple end groups;
Develop innovative solutions to overcome synthetic or biologic challenges through literature review and creative thinking;
Preparation of technical reports, patents, and oral presentation.

Requirements

D. in organic chemistry is required with a first significant experience;
Excellent laboratory skills and knowledge of organic synthesis and technics for purification;
Proficient in the use and interpretation of analysis (NMR, HPLC, MS, IR, DSC, ….);
Bibliographic research expertise;
Ability to work independently or in team environments;
Strong interpersonal skills and the ability to work in a fast paced, multidisciplinary team environment, with good organization, and an eye for detail;
Gather scientific intelligence to provide specific expertise when needed;
Ensure scientific and technologic watch;
Ability to be proactive and to innovate in problem solving;
Fluent English required;
Based in Strasbourg with travels to Paris.

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