Senior Scientist (Expression)

Senior Scientist (Expression)

Evotec

Macclesfield, United Kingdom

Key Accountabilities

• Design and execution of agreed work plans for early drug discovery projects.
• Responsible for supporting more than one project and may be asked to direct internal resources to achieve agreed goals.
• Will be expected to provide oversight of results to ensure quality to project specifications.
• Accountable, together with project counterparts, for the design of experiment, review of documentation and client presentations. Will conduct thorough data analysis ahead of product release to internal or external customers.
• Proposes experimental designs and novel approaches to identify/advance best strategies in addition to planning/ executing project deliverables.
• Responsible for the implementation of standalone scientific services and deliverables to customers.
• Where responsible for reports will lead colleagues to co-develop plans for personal growth, aligned to business need.
• Represent the company at scientific and/or business conferences.
• Presents and publishes as appropriate peer-reviewed science increasing own and Evotec’s scientific reputation.

Knowledge & Experience

• Strong technical knowledge of recombinant protein expression and protein biochemistry with a proven ability to deliver high-quality protein reagents for early drug discovery projects.
• Extensive hands-on experience in insect cell expression systems, including Baculovirus Expression Vector Systems (BEVS) and Drosophila S2 cell expression.
• Design, clone and optimise expression constructs specifically for production of recombinant proteins in insect cell platforms.
• Generate, amplify and characterise recombinant baculoviruses to support protein production campaigns.
• Execute small-scale screening and large-scale insect cell expression experiments to maximise protein yield, quality, and functionality.
• Maintain and optimise insect cell cultures, including Sf9, Sf21, S2 and High Five (Tni) cell lines.
• Develop and troubleshoot insect cell expression strategies for challenging targets, including membrane proteins, multiprotein complexes and difficult-to-express proteins.
• Assess protein expression and quality using SDS-PAGE, Western blotting and relevant analytical techniques.
• Interpret experimental data and make informed technical recommendations to improve expression outcomes.
• Demonstrated ability to troubleshoot complex expression challenges using a scientific and data-driven approach.
• Understanding of the scientific and technical background underpinning protein expression experiments and their application to drug discovery.
• Experience executing work plans with a high degree of accuracy and attention to detail.
• Expected to work independently on routine activities and make day-to-day technical decisions within their area of expertise.
• Expected to follow training provided on the correct use and maintenance of laboratory equipment.

Education and Qualifications

• PhD or a Degree with corresponding experience in a relevant scientific discipline ideally with relevant experience within industry.