Scientist I/II - Biology

Ryvu Therapeutics

Laboratory-based role: approximately 70% wet lab work, 30% data analysis and conceptual input
Establishment and maintenance of primary cell cultures
Design and execution of complex and technically challenging experiments, including:
- Whole-genome CRISPR screens for target identification
- Target validation studies
- Secondary functional assays in pharmacology
Biological data interpretation and drawing relevant scientific conclusions
Development and implementation of new research methods and protocols based on project needs
Continuous literature review and integration of findings into project strategies
Independent management of dedicated sub-projects
Regular presentation of research results and methodologies in internal meetings and project reviews

MSc in Molecular Biology, Biotechnology, or related field with at least 2 years of experience in academia or industry, or a PhD degree
Previous experience in cancer biology is highly desirable
Proven experience in developing 2D and 3D cell-based assays
Hands-on expertise in mammalian cell culture, with experience in patient-derived and/or organoid models considered a plus, and common molecular biology techniques:
- ELISA, Western blot, qPCR, flow cytometry
- Cytotoxicity and proliferation assays
- Evaluation of drug synergy
Experience with medium-throughput cell-based assays in microplate format
Proficiency in data analysis software such as GraphPad Prism, Excel, FlowJo
Experience with primary cell cultures, biologics activity testing, and gene silencing/knock-out techniques (RNAi and/or CRISPR) is a plus
Strong analytical thinking, literature research skills, and ability to work independently
Eagerness to learn and apply new experimental methods
Good command of written and spoken English