Scientist/Senior Scientist - DMPK

Scientist/Senior Scientist - DMPK

Ryvu Therapeutics

Kraków, Poland

We are looking for a DMPK Scientist with hands-on experience in LC-MS/MS to support the discovery and development of innovative small molecules, biologics, and antibody-drug conjugates (ADCs).

KEY RESPONSIBILITIES

• Develop bioanalytical (especially LC/MS/MS) methods for the discovery and development of NCEs (New Chemical Entities) or NBEs (New Biological Entities).
• Operate and maintain LC-MS/MS instrumentation, ensuring proper calibration, troubleshooting, and routine maintenance.
• Planning and coordinating in vitro and in vivo DMPK/ADME studies, including metabolic stability, plasma protein binding, permeability, CYP inhibition/induction, drug-drug interaction risk, bioanalysis, pharmacokinetics, and tissue distribution studies.
• Analyzing, interpreting, and reporting DMPK and PK data to support compound profiling, candidate selection, and project decision-making.
• Collaborating with medicinal chemistry, biology, pharmacology, toxicology, bioanalysis, and project management teams to integrate DMPK findings into project plans.
• Managing interactions with CROs and external vendors, including study requests, protocol review, data quality checks, timelines, and report review.
• Preparing study summaries, technical reports, presentations, and data packages for internal project meetings.
• Maintaining accurate documentation of experimental plans, results, analyses, and conclusions in line with internal standards and applicable quality requirements.
• Monitoring scientific literature and applying relevant DMPK knowledge to ongoing projects.
• Prior experience in the field of ADC discovery or protein bioanalysis will be a plus.

YOUR BACKGROUND

• MSc or PhD in pharmaceutical sciences, pharmacology, biochemistry, chemistry, biology, toxicology, or a related life sciences discipline.
• Hands-on or project-based experience in DMPK, ADME, pharmacokinetics, bioanalysis, drug metabolism, or related areas.
• Proven experience (2+ years) in LC-MS/MS-based analysis.
• Good scientific writing and presentation skills.
• Strong organizational skills, attention to detail, and ability to manage multiple tasks and timelines.
• Good command of English, both written and spoken.
• A thorough understanding of bioanalytical methods for pharmacokinetics.
• Competency with basic PK data analysis would be desirable.
• Practical experience with mass spectrometry-based methods used in the proteomic and ADC bioanalysis would an advantage.