Scientist II: Bioconjugation & Protein Specialist

Scientist II: Bioconjugation & Protein Specialist

Ryvu Therapeutics

Kraków, Poland

We are looking for an experienced Scientist II – Bioconjugation & Protein Specialist with expertise in recombinant proteins, antibody technologies, and protein characterization to support the development of next-generation Antibody-Drug Conjugates (ADCs) in a collaborative, innovation-driven research environment.

KEY RESPONSIBILITIES

• Production of recombinant proteins using various expression systems.
• Production, handling, and processing of antibodies.
• Performing comprehensive Quality Control (QC) and characterization of proteins, antibodies, and bioconjugates using analytical techniques such as LC-SEC, HIC chromatography, DLS, nanoDSF, and related methods.
• Executing bioconjugation processes (linking antibodies with payload-linkers) to generate Antibody-Drug Conjugates (ADCs).
• Independently planning, executing, and troubleshooting complex experiments related to project goals.
• Analyzing experimental data, drawing conclusions, and presenting outcomes at internal seminars and external meetings.
• Collaborating cross-functionally with other scientific teams and liaising with external CROs.
• Actively managing assigned sub-projects or workflows within the laboratory.
• Maintaining accurate laboratory records, ensuring compliance with SOPs, QA policies, and Health & Safety regulations.
• Performing regular scientific literature searches and suggesting new conceptual ideas or technological innovations.

YOUR BACKGROUND

• PhD with at least 2 years of relevant experience, or MSc with at least 5 years of relevant experience in Biochemistry, Biotechnology, Molecular Biology, or a related field.
• Proven hands-on experience in recombinant protein expression across various systems and strong expertise in antibody production and handling.
• Demonstrated ability to work in aseptic conditions
• Understanding the theoretical and practical aspects of in vitro protein modification chemistry
• Extensive knowledge and practical skills in protein Quality Control (QC) and characterization (e.g., LC-SEC, HIC, DLS, nanoDSF).
• English proficiency at the C1+ level (fluent in both written and oral communication).
• Excellent team member with a flexible mindset, strong communication skills, and the ability to work independently.

Preferred Qualifications:

• Previous practical experience in the generation (bioconjugation) and analytical characterization of Antibody-Drug Conjugates (ADCs) is a strong plus.