Senior/Principal Scientist Biotransformations

Johnson & Johnson

Beerse, Belgium

The Translational ADME Biotransformation team in Beerse, Belgium, is looking for a highly motivated Senior or Principal Scientist to support drug discovery and development programs. The team is part of the department of Translational Pharmacokinetics/Pharmacodynamics and Investigative Toxicology (TPPIT) and plays a pivotal role in support of drug metabolism related studies for small and large molecule drug discovery and development programs as well as in developing and applying advanced analytical chemistry solutions to solve mechanistic questions.

We are a highly motivated team, and our laboratories are state-of-the-art. As part of the global Translational ADME community within TPPIT, you will have access to a large arsenal of in silico, in vitro, in vivo and analytical tools and the vast expertise of colleagues at our various research sites in Belgium and the United States.

Key Responsibilities

To manage and coordinate metabolite profiling and identification studies for a broad range of modalities (small molecules, degraders, peptides, oligonucleotides, etc.), including design, plan and conduct of in vitro incubations, perform high quality analysis and write high quality scientific reports
To perform liquid chromatography analysis with MS, UV and radioactive detection, including method development and data analysis and interpretation
Serve as a subject matter expert for biotransformations, putting data into broader context and suggest and develop follow-up in vitro or in vivo experiments
Effectively communicate data and their relevance to multidisciplinary project teams, management, and potential partners through internal and external presentations and publications
To keep abreast with the current advances in MS, automation and related technologies and apply new technologies and methods to increase sensitivity, quality and throughput

Qualifications

PhD in Medicinal/Organic Chemistry, Pharmaceutical Sciences, Biochemistry, Pharmacokinetics, Drug Metabolism or related field, or multiple years of relevant experience in the field of biotransformations
Hands-on experience in structure elucidation using mass spectrometry
In depth knowledge of biotransformation reactions and enzymes involved
Hands-on experience with non-small modalities (oligonucleotides, peptides and proteins) is an asset
Experience with bioinformatics applications is an asset
Experience in maintenance of chromatography and mass spectrometry instrumentation and developing and troubleshooting LC/RAD and LC/high-resolution MS assays
Ability to independently diagnose and solve complex technical and scientific problems
Team player with strong interpersonal skills in an international team setting, including a matrix environment
Proven track record of scientific achievement & project influence through publications and other interactions
The working language is English