Senior Clinical Pharmacologist

Idorsia Pharmaceuticals

Allschwil, Switzerland

We are seeking an experienced, entrepreneurial Senior Clinical Pharmacologist to join our organization. In this role, you will operate in a lean, fast-paced environment with established core processes and systems, influencing the clinical pharmacology strategy across a high volume of First-in-Human (FIH) and early clinical programs, as well as ongoing studies.

This is a hands-on, high-impact role within Global Clinical Development, offering significant visibility and growth potential in the organization, and requiring close collaboration with Translational Research.

Key Responsibilities

Lead the design and execution of clinical pharmacology strategies and corresponding studies across multiple programs;
Develop innovative and meaningful clinical pharmacology approaches that accelerate and de-risk drug development;
Define dose selection, escalation strategies, and characterize exposure-response relationships;
Ensure integration of nonclinical, translational, biomarker and clinical data to inform development decisions;
Design clinical studies with appropriate pharmacokinetic (PK) and pharmacodynamic (PD) endpoints;
Apply biomarkers and model-informed drug development (MIDD) approaches to enhance study design and decision-making;
Author and contribute to protocol development, including statistical and modeling/simulation considerations;
Serve as the primary clinical pharmacology interface with: Research, Translational Sciences, Biostatistics, Regulatory Affairs;
Represent clinical pharmacology at life cycle meetings;
Lead scientific discussions and provide strategic input in program governance meetings and decision-making forums;
Manage a large inflow of new clinical candidates alongside ongoing studies;
Author and contribute to regulatory documentation (IND/CTA, briefing documents, health authority responses);
Represent clinical pharmacology in agency interactions as a subject matter expert;
Manage and oversee external partners (CROs, modeling vendors).

Qualifications & Experience

PhD, PharmD, MD, or equivalent in Clinical Pharmacology, Pharmacokinetics, or related field;
10+ years of job relevant industry experience in biotech/pharma;
Proven track record in:
- Early clinical development (FIH through proof-of-concept);
- Study design and dose justification;
- PK/PD modeling and interpretation.
Experience managing multiple concurrent programs in a dynamic environment;
Entrepreneurial mindset and intellectual curiosity with ability to thrive in ambiguity and rapid change;
Strong scientific leadership with a hands-on, execution-oriented approach;
Demonstrated ability to translate clinical pharmacology data into high-quality manuscripts, abstracts, and conference presentations;
Excellent cross-functional collaboration and influencing skills;
Ability to balance strategic thinking with operational delivery.