Senior Scientist Protein Purification & Automation

Senior Scientist Protein Purification & Automation

Evotec

Macclesfield, United Kingdom

We are seeking a highly skilled and innovative Senior Scientist to join our Protein Biochemistry team, with a primary focus on protein purification and automation at scale.

This role requires deep technical expertise in high-throughput purification workflows, including the handling of complex, aggregation-prone, and otherwise difficult to purify proteins. You will play a key role in designing, implementing, and scaling automated purification platforms, while ensuring delivery of high-quality protein and data to support drug discovery programs. Through hands-on scientific leadership, you will drive multiple projects simultaneously and contribute to advancing both platform capabilities and scientific excellence

Key Accountabilities 

• Design, optimise, and execute robust protein purification workflows (manual and automated) across multiple scales.
• Lead development of high-throughput purification platforms, including multi-step automated workflows.
• Apply advanced strategies to purify challenging, unstable, aggregation-prone, or low-yield proteins.
• Integrate purification workflows with expression and characterisation pipelines to maximise throughput and data quality.
• Develop and implement protein purification workflows using liquid handling systems and ÄKTA platforms.
• Drive automation of complex, multi-step purification processes.
• Contribute to digital workflow development (e.g., LIMS integration, data capture, traceability).
• Leverage programming (e.g., Python or equivalent) to enhance automation, data handling, and process optimisation.
• Design and implement protein characterisation strategies (e.g., purity, stability, aggregation, activity).
• Ensure high-quality, quality controlled, reproducible data generation and documentation.
• Responsible for supporting multiple projects and may be asked to direct internal resources efficiently to achieve agreed goals.
• Where responsible for reports, will lead colleagues to co-develop plans for personal growth, aligned to business need.
• Represent the company at scientific and/or business conferences.
• Presents and publishes as appropriate peer-reviewed science increasing own and Evotec’s scientific reputation.

Knowledge & Experience 

Extensive experience in recombinant protein purification, with clear expertise in:

• High-throughput purification strategies through automation and scale-up
• Extensive experience with difficult protein targets (unstable, aggregation-prone)
• Strong hands-on experience with chromatography systems (e.g., ÄKTA) and Liquid handling / automation platforms supporting protein purification workflows
• Proven track record of designing and optimising purification workflows end-to-end.
• Experience delivering high-quality protein and data under tight timelines.
• Strong understanding of protein biochemistry within drug discovery workflows.
• Demonstrated ability to solve complex technical problems and troubleshoot purification challenges.
• Experience in working with cell free expression systems is desirable
• Programming or scripting skills (e.g., Python) for automation and data processing and familiarity with LIMS and digital lab workflows.
• Experience with in silico-based tools for sequence and structural analysis is desired.
• Experience of preparing and executing workplans and building trusted partnership with internal and external customers. Requires a track record of leading scientists across specialist fields.
• Requires a track record of facilitating employee growth through co-development of personal development plans.
• Track record of successful problem-solving, high-quality science and influencing of stakeholders and colleagues.
• Experience of scientific development and research work ideally with publications in a relevant scientific field.

Education and Qualifications

• Ideally a Ph.D. degree or corresponding experience in a relevant scientific discipline with > 5 years of relevant experience in industry. Alternatively, a relevant first degree and several years additional experience in drug discovery.