Scientist I (Biologics & Assays)

Evotec

Macclesfield, United Kingdom

Purpose of the Role

Responsible execution of work plans for their protein science area. Accountable for delivery from early drug discovery workflows in their area of expertise.

Key Accountabilities

Execution of approved work plans in early drug discovery projects.
Provide recommendations for improving Workplans for review and approved by Grade 5 or above
Responsible for supporting more than one project across modalities and therapeutic areas
Will be expected to deliver timely, accurate results of pre-agreed quality to project specifications.
May conduct some data analysis ahead of internal review prior to release to internal or external customers.

Knowledge & Experience

Technical knowledge of Protein Biochemistry, Structural Biology or Biophysics with a proven ability to deliver results across target families within agreed timelines and budget, meeting agreed quality criteria.
Design and engineer recombinant proteins, antibodies and biologics using advanced molecular biology techniques.
Express proteins in bacterial, mammalian, and insect systems with optimised yield and quality.
Purify proteins using automated chromatography platforms (ÄKTA; affinity, ion‑exchange, SEC).
Characterise proteins with biophysical and biochemical methods (CE, plate‑based assays, DLS, nDSF, HPLC).
Troubleshoot expression and purification challenges, applying creative problem‑solving to refine workflow
Understanding of scientific and technical background of experiments.
Experience of precise execution of workplans.
Expected to have some independence, making day-to-day technical decisions
Expected to follow training provided on the correct use and maintenance of lab. equipment