Principal DMPK Scientist

Servier

Gif-sur-Yvette, France

Make an impact at the interface of discovery and development

Join Servier’s Translational Medicine (TxM) organization to steer programs from early research toward first-in-human, turning robust science into real patient benefit.

You will lead TxM strategy and activities in the project Core Team and represent non-clinical DMPK strategy from late research onward - partnering across ADME/DMPK, non-clinical safety, quantitative pharmacology, formulation, and clinical pharmacology to de-risk and accelerate our pipeline in Oncology and Neurology.

This is a full-time position for our new R&D site in Paris - Saclay with possibility of some remote work.

Responsibilities

As an early TxM lead, the candidate will:

Be the representative of TxM in the Core Team (CT) in research projects up to clinical candidate selection;
Lead the TxM sub-team and engage with relevant functional experts to ensure project progression;
Be the subject matter expert in ADME/DMPK and/or non clinical safety, ensuring data analysis and interpretation;
Define the TxM and project strategy and lead required work packages; work with Function Managers to form sub-teams to deliver the work packages;
Actively participate in governance meetings (TxM and R&D);
Support and challenge the CT strategy as integral member of the CT (going beyond the functional TxM expertise – contributor role);
Communicate to the CT and from the CT to the function (ambassador role) and ensure TxM functional input is reflected in the CT/TxM strategy;
Work in close interaction with project lead and project manager to define and mitigate risks, ensure adherence to project plan (timeline, costs/resources, quality).

As a non-clinical DMPK rep (from late research), the candidate will:

Define the nonclinical DMPK strategy and operational plan of the project in collaboration with the project leader and other functional leads to mitigate risk, and maximize probability of success;
Participate in project team meetings as a recognized DMPK expert;
Provide scientific leadership and training within and outside the team;
Write/Review protocols, scientific reports and prepare appropriate documentation to support regulatory agency filings. Provide DMPK expertise into related documents such as Investigator’s Brochures, project strategic documents and study reports;
Follow external scientific advances in the area of drug metabolism and pharmacokinetics and promote and implement relevant technologies & methods internally to ensure state-of-the-art capabilities and continuous support for projects;
Ensure good communication with other partners in the project team and sub-teams (non-clinical safety, Pharmacology, Quantitative pharmacology, Clinical pharmacology, early formulation, ….). Interact with those teams in a matrix environment;
Participate actively in operational performance monitoring by ensuring that resources and timelines are met for deliverables for which there is a contribution or accountability.

Profile

Ph. D. degree (or equivalent experience) in chemistry, pharmacology or related discipline;
Strong experience in DMPK field in Drug Discovery and Development Programs;
Experience in multiple drug modalities (ASOs, Protacs, NBEs) is an asset;
Experience in interacting with external partners and contract research organizations (CROs) is a plus;
Good understanding of drug discovery programs and in depth understanding of structure property relationships in ADME and toxicology;
Experience in drug discovery, drug design and multi-parameter optimization with a “drug hunter” mindset;
Good understanding of in silico ADME and toxicity prediction tools and their application to drug design;
In depth knowledge of the DMPK discipline and a good knowledge of non-clinical safety assessment;
Experience in application of Artificial Intelligence driven approaches to drug discovery and development is a plus;
Strong DMPK experience in drug development programs and regulatory interactions;
Experience in drug-drug interaction assessment, biotransformation (including Metabolites in Safety Testing) and relevant methodologies and approaches.
Communication skills:
- Excellent communication, presentation, interpersonal skills, with an ability to inform, influence, and persuade;
- Assertiveness, ability to influence decision making in project core teams to facilitate project progression;
- Ability to work independently to drive project forward as well as collaboratively in a multidisciplinary team (matrix) environment;
- Good listening and writing skills in English.