Bench Scientist In Vitro Biology

VIE Contract

Sanofi

Frankfurt am Main, Germany

About the job

As Bench Scientist In Vitro Biology VIE within our In Vitro ADME team, you’ll be supporting the team who facilitates and speeds up research and development of large therapeutic molecules in a highly competitive landscape with deeper understanding of transport and metabolism mechanisms. This can be achieved through the creation and validation of transgenic 2D and 3D in vitro barrier models, followed by experiments utilizing confocal microscopy to elucidate the mechanisms of receptor-mediated endocytosis and transcytosis and quantification by mass-spectrometry.

Main responsibilities:

Develop and validate innovative transgenic 2D and 3D in vitro cell culture models for mechanistic studies of receptor-mediated endocytosis and transcytosis of large therapeutic molecules (e.g. antibodies) using confocal microscopy and LC/MS;
Conduct and document experiments to elucidate the mechanisms of receptor-mediated endocytosis and transcytosis of large molecules;
Develop new approaches of data interpretation and correlation with e.g. Machine Learning;
Analyze data and prepare reports, posters and presentations;
Present findings to the team and possibly at scientific conferences.

About you

Experience:

Experience with cell culture techniques, including transfection methods;
Prior experience working with confocal microscopy and/or large molecules LC/MS.

Soft and technical skills:

Knowledge of MS Office (Excel/Word/Powerpoint);
Scripting language/data science skills (Python, R) would be an asset.

Education:

Master’s Degree in a biological field such as molecular biotechnology, molecular/cell biology, biochemistry, pharmacy or similar. PhD would be appreciated.