Senior Scientist - Process Chemistry Development

Sanofi

Montpellier, France

About the job:

As Senior Scientist - Process Chemistry Development within our Commercial Process Development team, you'll design and optimize synthetic pathways for drug substances undergoing clinical development. Ready to get started?

You'll join our CMC Synthetics Platform team, where we focus on mid-to-late-stage process development for our most promising drug candidates. Our team drives innovation through cutting-edge synthetic concepts, artificial intelligence and machine learning applications, and biocatalysis approaches to deliver efficient, scalable manufacturing processes.

Main responsibilities:

Contribute to the design of novel and efficient synthetic pathways for drug substances undergoing clinical development;
Conduct and oversee route scouting in laboratory to demonstrate synthetic viability;
Use all imaginable chemistry tools and methods to develop and optimize commercial process for selected drug substance route (photochemistry, biocatalysis, flow chemistry, electrochemistry, on-line analysis/PAT, high-throughput experimentation, structural analysis, computational chemistry, etc.);
Design, plan and execute experimental plans to optimize reaction, purification and isolation unit operations, guided by technical risk assessments, to deliver safe, efficient, robust and scalable drug substance manufacturing processes that perform reliably at intended scale in batch or continuous format;
Collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization;
Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development reports, project discussions and presentations;
Provide concise technical presentations to communicate work to project teams, cross functional teams and management;
Document all work on projects and continuous improvements in eLNB experiments and summarize in technical reports;
Establish/extend external network by providing representation and leadership on academic, industrial, or government sponsored collaborations;
Champion continuous improvements through pursuit of scientific and technical innovations, workflow optimizations, and incorporation of digital tools.

About you

Experience:

PhD with 3-5 years of pharmaceutical or chemical industry experience in process chemistry or synthetic organic chemistry;
Post-doctoral research experience preferred.

Soft and technical skills:

Strong expertise in synthetic organic chemistry, process optimization, and scale-up principles;
Experience with analytical techniques, statistical analysis, and project management;
Excellent problem-solving abilities, communication skills, and ability to work effectively in cross-functional teams.