Scientist Protein Chemistry

Scientist Protein Chemistry

Ascendis Pharma

Heidelberg, Germany

Description

Ascendis Pharma is looking for a highly driven Associate Scientist (M.Sc.) or Scientist (Ph.D.) to join our Protein Chemistry team. In this role, you will play a key part in the design, synthesis, and characterization of therapeutic protein conjugates, supporting pre-clinical in vitro and in vivo studies.

We are seeking a creative and collaborative scientist with a proactive mindset, strong problem-solving abilities, and a hands-on background in protein chemistry and bioconjugation. A positive, can-do attitude and a passion for innovation are essential.

Are you energized by working in a team-oriented environment where mutual support, open communication, and knowledge sharing are part of the daily routine? Do you enjoy pushing the boundaries of science - exploring new ideas, technologies, and approaches - while maintaining a strong foundation of analytical rigor and critical thinking? Do you thrive on tackling complex scientific problems and excel in dynamic environments where priorities shift and goals evolve? Are you passionate about using your scientific expertise to contribute to the development of innovative therapies that make a real difference in patients’ lives?

Your Responsibilities

• Design and optimize synthesis and purification workflows for protein conjugates;
• Develop and implement advanced chromatographic and mass spectrometric techniques;
• Conduct comprehensive characterization of protein conjugates, focusing on release profiles, stability, and biological activity;
• Explore and assess innovative technologies to enhance our existing platform capabilities;
• Communicate findings effectively within cross-functional project teams;
• Prepare detailed scientific documentation, including technical reports and patent example drafts;
• Perform in-depth literature reviews to support ongoing research and development.

Requirements

• Exceptional Master’s degree (Associate Scientist) or doctoral degree (Scientist) in biochemistry or a closely related field;
• Strong theoretical foundation and hands-on expertise in protein chemistry and analytical techniques, including SEC, IEC, SDS-PAGE, RP-HPLC, bioconjugation, and TFF;
• Demonstrated proficiency in operating Äkta and Agilent chromatography systems;
• Solid understanding of protein mass spectrometry;
• Proven creativity in developing synthetic strategies for complex protein conjugates;
• Collaborative mindset with a strong interest in interdisciplinary research;
• Independent, well-organized, and methodical approach to work;
• Excellent written and verbal communication skills in English; working proficiency in German is desirable.