Expert GPCR Cellular Assays

Expert GPCR Cellular Assays

Proteros Biostructures

Munich, Germany

Your mission

• Contribute to multidisciplinary and challenging research projects in the field of drug discovery.
• Provide expert knowledge in GPCR biology, focusing on GPCR/G-protein interactions and ligand pharmacology.
• Independently design, execute, and interpret cellular functional assays for profiling and classifying ligands based on their mode of stimulation.
• Develop and apply fluorescence and luminescence assays with continuous kinetic readout on FLIPR or FDSS workstations.
• Perform ligand screening in HTS mode and ligand profiling experiments.
• Utilize cell culture techniques and select relevant cell lines.
• Ensure compliance with industry standards for screening, profiling, and characterization of ligand–GPCR binding.
• Maintain thorough documentation of work according to internal guidelines and customer requirements using a laboratory management system (LIMS).

Your profile

• Ph.D. in cell biology, pharmacology, biochemistry, or a related field, with a strong focus on membrane protein signaling.
• At least 3 years of experience in a drug discovery environment, covering the process from screening to lead identification.
• Deep understanding of GPCR pharmacology and G-protein interactions.
• Hands-on experience with FLIPR or FDSS workstations.
• Proven expertise in other fluorescence- and luminescence-based GPCR assay technologies, such as TR-FRET, FRET, nanoBRET.
• Strong analytical and problem-solving skills with a high level of accuracy and attention to detail.
• Ability to work independently and in interdisciplinary teams across different projects.

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