Lead Scientist - Purification Development and Viral Clearance

Lead Scientist - Purification Development and Viral Clearance

Lonza

Slough, United Kingdom

The Lead Scientist is a key member of the laboratory team who works on multiple complex projects to resolve challenging technical issues and deliver high quality execution of experimental work follow rig all safety and quality procedures.

They are responsible for planning and executing complex experiments and supporting more junior colleagues to plan and execute their projects

Key responsibilities:

• Plan and design own experiments for development of downstream processes for therapeutic proteins;
• Design and execution of high throughput chromatography methods;
• Responsible for the execution and delivery of own projects with particular attention to safety, quality, on time and right first time;
• Escalate technical issues in a timely fashion;
• Ensure that experimental details, raw data and results are recorded as appropriately;
• Collate, analyse and evaluate data to produce good quality process information;
• Operate as part of a cross-functional project team;
• Prepare and deliver presentations, protocols and reports;
• Contribute to the efficient running of the laboratories.

Key requirements:

• BSc/PhD in Biotechnology or in a relevant scientific discipline and appropriate laboratory experience;
• Tecan Evo and/or Tecan Fluent programming experience;
• Hands on knowledge of protein chemistry and protein purification;
• Practical experience with laboratory scale AKTA chromatography;
• Strong written and verbal communication skills;
• Strong planning and organisational skills;
• IT proficient (i.e. Microsoft Office);
• Proficient in the use of Unicorn software.

Desirable:

• Knowledge of GLP/GMP;
• Experience of process transfer and scale up to cGMP manufacture;
• Experience of managing external stakeholders;
• Knowledge of GAP analysis methodologies (e.g. FMEA, Cause and effect analysis);
• Experience of process characterisation/validation;
• Operational excellence (5S or similar) experience.

Qualities and Attitude:

• Excellent attention to detail;
• Must have excellent interpersonal skills to work effectively as part of a multidisciplinary/project team;
• Prioritise and manage own time effectively;
• Show initiative for problem solving and generating new ideas;
• Create and support the work plans of the teams;
• Able to support and mentor more junior members;
• Comfortable working in a fast paced environment with changing priorities;
• Willingness to support other activities within the department.

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