Discovery Safety Scientist

Evotec

Multiple Locations

We are looking for a discovery toxicologist to provide significant support to our extensive portfolio of drug discovery programs. Working in close collaboration with relevant disciplines at Evotec and those of our partners, you will apply your deep understanding of discovery toxicology to rapidly advance projects from target identification to preclinical development. Working across a diverse range of indications and modalities, you will be responsible for the nonclinical safety strategy of multiple projects, including the design, interpretation, reporting and communication of discovery safety studies. This role reports to the VP Project Toxicology and Discovery Safety and may be based at any of our global offices with the potential for flexible working arrangements available.

Main Responsibilities will include

Responsible for the scientific oversight of discovery toxicology studies conducted across multiple projects at Evotec
Analyse, interpret and present toxicology data to project teams, updating risk assessments and applying knowledge and experience to impact project decisions
Develop and oversee target de-risking strategies for new projects based on the outcomes of target safety assessments
Provide timely safety/toxicology guidance to project teams at all stages of the drug development process
Provide project teams with an understanding of the predictivity of in silico and in vitro toxicology methods, their translatability in vivo and the associated clinical impact
Bridge the gap between discovery and development toxicology, allowing more consistency and streamlining of processes that affect project progression
Keep up to date with the latest NAMs and their potential to impact current paradigms at Evotec

Knowledge and Experience

Significant and varied experience working in the field of toxicology, with a detailed working knowledge of at least one area of discovery toxicology
Sound knowledge of designing and delivering nonclinical safety development strategies for small molecules and biologics in the pharmaceutical industry
Experience in experimental design and data interpretation of early safety studies and their translatability relating to drug development
Working knowledge of GLP regulations, ICH, OECD, FDA, EMA and other regulatory guidelines, and their application to the design of appropriate non-clinical safety studies
Knowledge of early target safety assessments with a focus on target de-risking strategies using bespoke or globally accepted in vitro techniques
Strong organisational and communication skills
Ability to work under pressure, manage multiple projects and deliver to defined timelines
Familiarity with working within small and large molecule drug discovery programs as a nonclinical safety representative with a basic understanding of associated disciplines, e.g. biomarkers, DMPK, biology, medicinal chemistry
Knowledge of predictive in vivo toxicology studies routinely performed during early phases of drug development
Awareness of in silico toxicology and how predictions can guide risk strategies for project teams