(Senior) Scientist - High Throughput Screening

(Senior) Scientist - High Throughput Screening

Selvita

Kraków, Poland

Key responsibilities

• Assistance in the design and construction of the HTS platform;
• Developing target-relevant biochemical and cell-based assays including optimization, validation and troubleshooting (screening assay robustness, sensitivity, reproducibility);
• Evaluation of the novel cell-based screening initiatives for implementation into the group portfolio;
• Converting assays into HTS format - assay miniaturization to 384-well / 1536-well format;
• Design and implementation of the key in vitro pharmacology experiments for low-throughput compound profiling (efficacy, selectivity, mechanism of action);
• Performing HT screens and hit identification;
• Statistical analysis, reporting and critical data evaluation for providing a scientific contribution to internal drug discovery projects;
• Ensuring all tasks and responsibilities are performed according to industry-leading scientific and ethical standards and accurately documented in the lab electronic notebook system.

Your background

• MSc in pharmacology, molecular biology, biotechnology or similar discipline with minimum 2 years of experience in a biotech/pharma setting or Ph.D. in relevant biological sciences;
• Good knowledge of in vitro pharmacology concepts with a strong focus on at least one of the following areas: intracellular signaling, cancer metabolism, immunology, CNS;
• Experience in working with cell lines and cell-based assays in microplate format;
• Prior experience with mid-to-high throughput screening, liquid handling devices and lab automation will be a plus;
• Analytical and problem-solving skills with proven troubleshooting experience;
• Well-developed multi-tasking, flexibility and team working skills;
• scientific presentation and interpersonal communication skills;
• Fluency in English.

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