Senior Research Associate, Biochemical Analysis

Senior Research Associate, Biochemical Analysis

Genmab

Utrecht, Netherlands

The Role

As a Senior Research Associate the Biochemical Analysis team within the Chemistry Manufacturing Control (CMC) Science and Technologies department, you will be responsible for setting up and performing several different types of experiments linked to antibody characterization, analytical development, and in-use/compatibility studies.

These studies support the early and late development stages of Genmab’s antibody pipeline, directly contributing to Genmab’s core mission to develop new antibody therapeutics!

You will combine laboratory work with data analysis, data interpretation and documentation. In addition, you will be responsible to coordinate the laboratory work of different projects and present data to other teams within Genmab’s CMC Utrecht and Copenhagen. Given that we are constantly looking for ways to optimize our processes, you will also help develop and implement new methods and techniques.

Responsibilities

• Clinical In-use activities include, compatibility and stability of the different drugs with the materials used in the clinic. These activities are crucial for the Investigation New Drug (IND) documentation for First-In-Human Clinical trials.
• Analytical method development includes qualification and development of several biochemical methods and transfer of the methods to/from Contract Research/Manufacturing Organizations (CROs/CMOs) and Genmab partners.
• Characterization activities include stability testing of therapeutic antibodies at different temperatures for predefined durations (days/months), stress studies, IND and BLA enabling studies.
• You perform experiments using a wide range of modern biochemical techniques in several simultaneous projects (e.g., HPLC, CE-SDS, icIEF, MFI, HIAC etc.).
• You will carry out most experiments according to Standard Operating Procedures (SOP) and study-specific protocols, which require high accuracy.
• You document and report the results clearly and correctly in an electronic lab book and present the results and interpretations to colleagues.
• You contribute to the method optimization and tech innovation of our team.
• You act as a Subject Matter Expert (SME) of one or more laboratory instruments.

Requirements

• You have completed a Master’s degree study in biochemistry, molecular biology or a related field. Applicants with a bachelor’s degree and relevant experience are also considered. This role is designed for candidates with hands-on industry experience, and those holding a PhD are considered overqualified.
• You have up to two (2) years of experience for the Research Associate level and at least two (2) years of work experience for the Senior Research Associate level, preferably in protein analysis and antibodies.
• Experience with analytical development processes is an advantage.
• You have hands-on experience in at least one of the following techniques: Absorbance Spectroscopy, Capillary Electrophoresis (CE-SDS and icIEF), Analytical Chromatography (HPLC), Micro-flow imaging (MFI), High Accuracy liquid particle counter (HIAC).
• You are familiar with basic data analysis software (e.g. Excel, JMP or GraphPad Prism). An interest in software and data handling is an advantage.
• You can work with tight deadlines and are capable of running several projects in parallel and adjusting priorities appropriately.
• You are motivated by delivering high-quality output and are used to working according to standardized procedures.
• You are a team player, but you are also capable of working independently.
• You have good oral and written communication skills in English.

About You

• You are genuinely passionate about our purpose.
• You bring precision and excellence to all that you do.
• You believe in our rooted-in-science approach to problem-solving.
• You are a generous collaborator who can work in teams with a broad spectrum of backgrounds.
• You take pride in enabling the best work of others on the team.
• You can grapple with the unknown and be innovative.
• You have experience working in a fast-growing, dynamic company (or a strong desire to).
• You work hard and are not afraid to have a little fun while you do so!

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