Senior Scientist I - Genetic Medicine Drug Product Development

Senior Scientist I - Genetic Medicine Drug Product Development

AbbVie

Ludwigshafen, Germany

Job Description

Join our team in the development of adeno-associated virus (AAV) formulations for gene therapy applications and other modalities such as monoclonal antibodies in the field of biopharmaceuticals.

Make your mark by:

• Drive the development of stable formulations. Design and execute experiments in the lab to characterize and optimize formulation candidates and demonstrate suitability of methods. Identify and implement the best-suited analytical methodologies.
• Initiate, collaborate and manage local and international teams, including Discovery, Analytics, Container Closure Sciences, and Process Development. Collaborate closely with cross-functional Chemistry, Manufacturing, and Controls (CMC) teams to ensure alignment on project goals and timelines. Participate in CMC teams as representative of drug product development.
• Contribute in establishing AAV formulation development capabilities (i.e., lab infrastructure and analytical instruments). Work alongside experts from various disciplines, utilizing cutting-edge equipment, and adapting to emerging technologies and challenges.
• Document experiments and results clearly and accurately in electronic laboratory notebooks.
• Report on experimental work and progress to peers, management, and partnering stakeholders.
• Prepare and contribute to essential documentation for regulatory submissions.
• Stay updated on advances in formulation development strategies and technologies, including attendance at relevant conferences.
• Identify and develop novel methods in partnership with the analytical development team.
• Prepare patents and manuscripts for publication in scientific journals and contribute to scientific dialogue within AbbVie’s global scientific community.
• Mentor junior scientists, sharing knowledge and best practices in AAV development.
• Manage and maintain lab equipment and supplies, ensuring a safe and efficient work environment.

Qualifications

This is how you can make a difference:

• PhD or equivalent education in pharmacy, virology, biotechnology, biology, or related fields. Practical experience is a plus, optimally in an industrial environment. Experience in development work/analytics with AAVs is a significant plus.
• Proficiency in common analytical methods for biopharmaceutical products, including but not limited to Dynamic Light Scattering, Liquid Chromatography, Capillary Electrophoresis, Plate-based Binding Assays, Spectrophotometry, osmometry, viscosimetry, etc.
• Proven track record of conducting high-quality research, encompassing experimental design, data analysis, and interpretation.
• Experience in authoring technical reports in English, including data interpretation for regulatory submissions.
• Strong communication and team collaboration skills to effectively contribute to multidisciplinary team environments and collaborative research projects.
• Experience with working in CMC teams is a plus.
• Personal initiative and problem-solving capabilities to develop innovative solutions within pharmaceutical development challenges.
• Strong written and verbal communication skills, with a demonstrated ability to publish and present scientific results.
• Fluency in English is mandatory, German language knowledge is a plus.

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